Smurf2 CLIA Kit for Mouse(Mus musculus) | EIAab.comSmurf2 CLIA Kit for Mouse(Mus musculus)

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Smurf2 (Gene name),

E3 ubiquitin-protein ligase SMURF2 (Protein name ), SMUF2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Smurf2;

Protein name:

E3 ubiquitin-protein ligase SMURF2;

Alternative:

SMAD-specific E3 ubiquitin-protein ligase 2;SMAD ubiquitination regulatory factor 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (via WW domains) with SMAD1. Interacts (via WW domains) with SMAD2 (via PY-motif). Interacts (via WW domains) with SMAD3 (via PY-motif). Interacts with SMAD6. Interacts with SMAD7 (via PY-motif) and TGFBR1; SMAD7 recruits SMURF2 to the TGF-beta receptor and regulates its degradation. Does not interact with SMAD4; SMAD4 lacks a PY-motif. Interacts with AIMP1 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase.

Function:

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Subcellular Location:

Nucleus Cytoplasm Cell membrane Membrane raft Cytoplasmic in the presence of SMAD7 (By similarity). Co-localizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts (By similarity). Interacts with STAMBP and RNF11.

Protein Attributes:

Sequence length:

748

Sequence:

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700:

748:

HQIDACTNNL | PKAHTCFNRI | DIPPYESYEK | LYEKLLTAIE | ETCGFAVE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

A2A5Z6

String:

A2A5Z6

Pfam:

PF00168

KEGG:

mmu:66313

UniGene:

Mm.340955

Uniprot:

A2A5Z6

FOR

ELISA Kit for Mouse E3 ubiquitin-protein ligase SMURF2

Cat.:

E2373h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase SMURF2

Cat.:

E2373m

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SMURF2

Cat.:

U2373h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SMURF2

Cat.:

U2373m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SMURF2

Cat.:

P2373Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SMURF2

Cat.:

P2373Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SMURF2

Protein for Mouse E3 ubiquitin-protein ligase SMURF2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation."
Yamashita M. , Ying S.X. , Zhang G.M. , Li C. , Cheng S.Y. , Deng C.X. , Zhang Y.E.
Cell121:101-113(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: 129/SvJ.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
5.

"Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts."
Kaneki H. , Guo R. , Chen D. , Yao Z. , Schwarz E.M. , Zhang Y.E. , Boyce B.F. , Xing L.
J. Biol. Chem.281:4326-4333(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY TNF SIGNALING PATHWAY ACTIVATION
6.

"AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2."
Lee Y.S. , Han J.M. , Son S.H. , Choi J.W. , Jeon E.J. , Bae S.-C. , Park Y.I. , Kim S.
Biochem. Biophys. Res. Commun.371:395-400(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STABILIZATION BY SCYE1

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